Charlie and Eli Sisters live in a wild and hostile world. They have blood on their hands: the blood of criminals and innocent people alike... They have no scruples about killing. It's their job. Charlie, the younger brother, was born to kill. Eli, however, dreams of living a normal life. They are hired by the Commodore to find and kill a man. From Oregon to California, a ruthless hunt begins, an initiatory journey that will test this insane bond between the two brothers. A path that leads to their humanity?
Jacques Audiard made his directorial debut with Regarde les hommes tomber (1994), followed by Un héros très discret (A Self-Made Hero, 1996), Norme Française (1998), Sur mes lèvres (Read My Lips, 2001), De battre mon coeur s'est arrêté (The Beat That My Heart Skipped, 2005) and Un Prophète (A Prophet), winner of the Jury Grand Prix at the 2009 Cannes Festival. He returned to the Cannes competition with De rouille et d'os (Rust and Bone) in 2012 and Dheepan, winner of the Golden Palm in 2015. The Sisters Brothers received the Best Director Award at the last Venice Festival.